Samuel BERTRAND

Chimie Analytique

Lipidomique, Métabolomique, Métabolites/lipides fongiques

Samuel Bertrand is graduated in Chemistry by the Ecole Nationale Supérieure de Chimie of Lille, France (2003). In 2009 he finished his PhD in Medicinal Chemistry, supervised by Prof. O. Duval, by the Université d'Angers, France. After a period as project manager in valorisation of natural product by Vegepolys (French competitive cluster, Angers, France), he moved in 2010 to the Ecole de Pharmacie Genève-Lausanne, Université de Genève, Switzerland, where he worked as a post-doctoral researcher supervised by Prof. J.-L. Wolfender on metabolomics and fungal natural product research. Since 2013, he is Assistant Professor at Laboratoire Mer Molécules Santé (See, Molecules, Health lab.), UFR des Sciences Pharmaceutiques et Biologiques (School of pharmaceutical and biological sciences), Université de Nantes, France. His main field of interest is metabolomics approaches in fungal natural product and lipid drug discovery.

Publications:

Jansen J. J., Blanchet L., Buydens L. M.C., Bertrand S., Wolfender J.-L., « Projected Orthogonalized CHemical Encounter MONitoring (POCHEMON) for fungal interactions during co-culture », Metabolomics, DOI: 10.1007/s11306-014-0748-5

Wolfender J.L., Marti G., Thomas A., Bertrand S., « Current approaches and challenges for the metabolite profiling of complex natural extracts », Journal of Chromatography, A, DOI: 10.1016/j.chroma.2014.10.091

Bertrand S., Azzollini A., Schumpp O., Bohni N., Schrenzel J., Monod M., Gindro K., Wolfender J.-L., « Multi-well Fungal Co-Culture for de novo Metabolite-Induction in Time Series Studies based on Untargeted Metabolomics », Molecular BioSystems, 2014, 10, 2289-2298, DOI: 10.1039/c4mb00223g

Bertrand S., Bohni N., Schnee S., Gindro K., Wolfender J.-L., « Metabolite induction by microorganism co-culture - methods to tackle new chemical diversity for the discovery of pharmaceutically relevant metabolites », Biotechnology Advances, 2014, 32(6) 1180-1204, DOI: 10.1016/j.biotechadv.2014.03.001

Halabalaki M, Bertrand S, Stefanou A, Gindro K, Kostidis S, Mikros E, Skaltsounis AL, Wolfender J-L, « Sample preparation issues in NMR-based plant metabolomics: optimisation for Vitis woods samples », Phytochemical Analysis, 2014, 25(4), 350-356, DOI: 10.1002/pca.2497

Bertrand S., Petit C., Marcourt L. Ho R., Gindro K. Monod M., Wolfender J.-L., « HPLC profiling with at-line microdilution assay for the early identification of antifungal compounds in plants from French Polynesia », Phytochemistry Analysis, 2014, 25(2), 106-112, DOI: 10.1002/pca.2473

Giacomelli E., Bertrand S., Nievergelt A., Zwick V., Simoes-Pires C., Marcourt L., Rivara-Minten E., Cuendet M., Bisio A., Wolfender J.-L., « Cancer chemopreventive diterpenes from Salvia corrugata Vahl. », Phytochemistry, 2013, 96, 257-264, DOI: 10.1016/j.phytochem.2013.09.011

Bertrand S., Hélesbeux J.-J., Larcher G., Duval O., « Hydroxamate, a key pharmacophore exhibiting a wide range of biological activities », Mini-review in Medicinal Chemistry, 2013, 13(9), 1311-1326, link

Bertrand S., Schumpp O., Bohni N., Monod M., Gindro K., Wolfender J.-L., « De novo identification of induced metabolites in fungal co-culture of Trichophyton rubrum and Bionectria ochroleuca », Journal of Natural Products, 2013, 76(6), 1157-1165, DOI: 10.1021/np400258f

Bertrand S., Schumpp O., Bohni N., Bujard A., Azzollini A., Monod M., Gindro K., Wolfender J.-L., « Detection of metabolite induction in fungal co-cultures on solid media by high-throughput differential ultra high pressure liquid chromatography-time-of-flight mass spectrometry fingerprinting », Journal of Chromatography, A, 2013, 1292, 219-228, DOI: 10.1016/j.chroma.2013.01.098

Al-Massarani S. M., Bertrand S., Nievergelt A., El-Shafae A. M., Al-Howiriny T. A., Al-Musayeib N. M., Cuendet M., Wolfender J.-L.,, « Acylated Pregnane Glycosides from Caralluma sinaica », Phytochemistry, 2012, 79: 129-140, DOI: 10.1016/j.phytochem.2012.04.003

Bertrand S., Bouchara J.P., Venier M.C., Richomme P., Duval O., Larcher G., « Na-methyl coprogen B, a potential marker of the airway colonisation by Scedosporium apiospermum in patients with cystic fibrosis », Medical Mycology, 2010, 48(Suppl. 1), S98-S107, DOI: 10.3109/13693786.2010.503972

Bertrand S., Duval O., Hélesbeux J.J., Larcher G., Richomme P., « Synthesis of the trans-fusarinine scaffold », Tetrahedron Letters, 2010, 51(16), 2119-2122, DOI: 10.1016/j.tetlet.2010.02.058

Bertrand S., Larcher G., Landreau A., Richomme P., Duval O., Bouchara J.P., « Hydroxamate siderophores of Scedosporium apiospermum », Biometals, 2009, 22(6), 1019-1029, DOI: 10.1007/s10534-009-9253-0

O'Halloran N., James J. P., Downey C. A., O'Malley P., Duff T., Bertrand S., « Inter- and Intramolecular Cyclisation Reactions of Azoacetates Derived from Aryl Hydrazones of Ethylacetoacetate and Acetoacetanilides », Heterocycles, 2008, 75(11), 2681-2701, DOI: 10.3987/COM-08-11433