Julien BARC

Cardiovascular genetics et epigenetics
Cardiopathies and sudden cardiac death
Molecular mechanism of inherited cardiac arrhythmia

Julien Barc, INSERM Associate Researcher at the Institut du Thorax since 2015, Nantes, France. After a 3-year PhD training in genetics of cardiac arrhythmia in Nantes, he spent 5 years at the department of Experimental Cardiology of Amsterdam, NL, where he gained experience in the new technologies and approaches in genetics. Today back in the cardiovascular genetics department  (Dr. Schott), he is leading the research on the genetics of arrhythmia. He was the co-leader of a national network for young fellows in cardiovascular research (Réseau Avenir GRRC) from 2017 to 2020 and recently joined the “Scientist of tomorrow” nucleus of the European Society of Cardiology consisting of 6 European researchers.

After obtaining his PhD in 2009, he developed an independent research by obtaining a European Society of Cardiology research grant (2011), Van Gogh Programme (2012 and 2013) and the Lefoulon-Delalande Grant (2014). He received from the French Cardiology Society the prestigious Prize Edouard Coraboeuf 2014. He obtained a H2020 grant on the complex genetics of the Brugada syndrome (2015) and a “rising star” grant from the regional council of Pays De La Loire  (2017) to develop cardiac epigenetic projects in Nantes with the aim to investigate the role of the non-coding regions of the genome in diseases at risk of sudden cardiac death. J. Barc’s expertise in (epi)genetics has been recognized by leading a work package in the European Joint programme on rare diseases: LQTS-NEXT. More recently, Julien Barc launched international collaborative projects on rare and common variants respectively and dedicated to identify the role of regulatory regions on cardiac arrhythmia syndromes and risk stratification (ANR and the French federation of cardiology grants). His high level of research and collaboration with the Netherlands led him to be awarded the prestigious Descartes-Huygens 2019 prize by the Royal Netherlands Academy of Arts and Sciences

Researcher ID: K-5495-2014
http://orcid.org/0000-0003-4106-5946
 

• 5 publications majeures: (*contributions équivalentes)

1. Familial Catecholamine-Induced QT Prolongation in Unexplained Sudden Cardiac Death

Huchet F*, Kyndt F*, Barc J*, Thollet A, Charpentier F, Redon R, Schott JJ, le Marec H, Probst V, Gourraud JB. J Am Coll Cardiol. 2017 Mar 28;69(12):1642-1643 (IF:19.9)

2. Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study

Behr E*, Savio-Galimberti E*, Barc J*, Holst A*, …/…, Guicheney P*, Crotti L*; Uk10k Consortium, Jamshidi Y*. Cardiovasc Res. 2015 Feb 17. (IF:5.8)

3. Mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence

Marsman RF*, Barc J*, Beekman L, Alders M, Dooijes D, van den Wijngaard A, Ratbi I, Sefiani A, Bhuijan ZA, Wilde AA, Bezzina CR. J Am Coll Cardiol. 2013 Sep 16. S0735-1097(13) (IF:19.9)

4. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Bezzina CR*, Barc J*, Mizusawa Y*, Remme CA*, Gourraud JB*, …/…, Wilde AA*, Probst V*, Schott JJ*, Dina C*, Redon R*. Nat Genet. 2013 Sep;45(9):1044-9. (IF:35.2)

5. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

Louis-Dit-Picard H*, Barc J*, Trujillano D*, …/…, Hadchouel J*, Schott JJ*, Jeunemaitre X*. Nat Genet. 2012 Mar 11;44(4):456-60, S1-3 (IF:35.5)