Frédéric BLANCHARD

1998 : Doctorat d'Université, Science de la vie et de la santé, Laboratoire INSERM U601, Nantes. "Contribution à l'étude de la cytokine LIF et de ses récepteurs".

2001 : Chercheur post-doctorant, Roswell Park Cancer Institute, Buffalo, NY, USA. "Molecular mode of action of Interleukin-6-type cytokines".

2002 : Chercheur post-doctorant, laboratoire INSERM U601, Nantes. "Effets anti-tumoraux de l'OSM sur les mélanomes".

2002 : HDR, Chimie-Biologie spécialité santé, Université de Nantes.

2004 : Chercheur post-doctorant, laboratoire EA 3822 - INSERM ERI 7, Faculté de Médecine, Nantes. "Effets anti-tumoraux de l'Oncostatine M sur les ostéosarcomes".

2005 : Chargé de Recherche 1ère classe INSERM, laboratoire INSERM U957, Faculté de Médecine, Nantes.

2015 : Directeur de Recherche 2ème classe INSERM, laboratoire INSERM U1238, Faculté de Médecine, Nantes.

2022 : Directeur de Recherche 2ème classe INSERM, laboratoire INSERM U1229, Faculté dentaire, Nantes.

Researcher ID (web of science) : K-8018-2015
ORCID : https://orcid.org/0000-0003-1055-2573
Principales publications récentes

• De Lima J, Boutet MA, Bortolotti O, Chépeaux LA, Glasson Y, Dumé AS, Le Pluart A, Nerviani A, Fossati L, Michaud HA, Guicheux J, Le Goff B, Pitzalis C, Courties G, Apparailly F, Blanchard F. Spatial mapping of rheumatoid arthritis synovial niches reveals specific macrophage networks associated with response to therapy. BioRxiv (preprint) DOI: 10.1101/2023.10.20.563040
• Hascoët E, Blanchard F, Blin-Wakkach C, Guicheux J, Lesclous P, Cloitre A. New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis. Bone Res. 11:26, 2023.
• Boutet MA, Courties G, Nerviani A, Le Goff B, Apparailly F, Pitzalis C, Blanchard F. Novel insights into macrophage diversity in rheumatoid arthritis synovium. Autoimmun Rev. 20:102758, 2021.
• Herman J, Le Goff B, De Lima J, Brion R, Chevalier C, Blanchard F, Darrieutort-Laffite C. Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy. Arthritis Res Ther. 23:131, 2021.
• Najm A, Masson FM, Preuss P, Georges S, Ory B, Quillard T, Sood S, Goodyear CS, Veale DJ, Fearon U, Le Goff B, Blanchard F. miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol. 72:2030-2039, 2020.
• Darrieutort-Laffite C, Arnolfo P, Garraud T, Adrait A, Couté Y, Louarn G, Trichet V, Layrolle P, Le Goff B, Blanchard F. Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner. J Clin Med. 8:1544, 2019.
• El Jamal A, Briolay A, Mebarek S, Le Goff B, Blanchard F, Magne D, Brizuela L, Bougault C. Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis. J Bone Miner Res. 34:2264-76, 2019. 
• Humbert P, Brennan MÁ, Davison N, Rosset P, Trichet V, Blanchard F, Layrolle P. Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration. Front Immunol. 10:663, 2019.
• Garraud T, Harel M, Boutet MA, Le Goff B, Blanchard F. The enigmatic role of IL-38 in inflammatory diseases. Cytokine Growth Factor Rev. 39:26-35, 2018. 
• Boutet MA, Najm A, Bart G, Touchais S, Trichet V, Layrolle P, Gabay C, Palmer G, Blanchard F, Le Goff B. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. 76:1304-12, 2017.
• Boutet MA, Bart G, Gahier M, Amiaud J, Brulin B, Charrier C, Morel F, Lecron JC, Rolli-Derkinderen M, Bourreille A, Vigne S, Gabay C, Palmer G, Le Goff B, Blanchard F. Distinct Expression of IL-36a, b, g, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease. Clin Exp Immunol, 184:159-73, 2016.
• Flanagan-Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Sahu S, Haskins M, Blanchard F, Steet R. Cathepsin-Mediated Alterations In TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res, 31:535-48, 2016.
• Bougault C, Briolay A, Boutet MA, Pilet P, Delplace S, Le Goff B, Guicheux J, Blanchard F, Magne D. Wnt5a is expressed in spondyloarthritis and exerts opposite effects on enthesis and bone in murine organ and cell cultures. Transl Research, 166:627-38, 2015.
• Rabeony H, Vasseur P, Pohin M, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F. IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol, 45:2847-57, 2015.
• Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F. Oncostatin M, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol, 185:765-75, 2015.
• Guihard P, Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F. Induction of osteogenesis in mesenchymal stem cells by activated monocytes / macrophages depends on Oncostatin M signaling. Stem Cells. 30:762-72, 2012.
• Chemel M, Le Goff B, Brion R, Cozic C, Berreur M, Amiaud J, Bougras G, Touchais S, Blanchard F, Heymann MF, Berthelot JM, Verrecchia F, Heymann D. Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. Ann Rheum Dis. 71:150-4, 2012.