Academic staff

Catherine LEVISAGE

Research Director INSERM Deputy Head Inserm U1229 - Regenerative Medicine and Skeleton (RMeS) Group leader "HEAL: Hydrogels and joint regeneration"

UMR_S 1229 Médecine Régénératrice et Squelette

Contact details

INSERM UMR 1229, Regenerative Medicine and Skeleton, RMeS, School of Dental Surgery, University of Nantes, 1 Place Ricordeau - 44300 Nantes France

Phone: 0240412984 (n° interne : 312984)
Email: Catherine.Levisage@univ-nantes.fr
Personal Website: http://www.rmes.univ-nantes.fr/

Research topics

Hydrogels and joint microenvironment

My research interest lies in bioengineering approaches to orchestrate molecular and physical signals that regulate cell fate and recapitulate the cellular microenvironment's complexity. My most recent works have focused on innovative hydrogels as i) carriers of cells or bioactive molecules in the context of the intervertebral disc disease and osteoarthritis and ii) biofabrication tools for developing in vitro models.

Activities / Resume

See my online CV

2017- : Deputy Director. Regenerative Medicine and Skeleton (RMeS) Laboratory, Nantes, France
2012- : Research Director. National Institute of Health and Medical Research, Nantes, France
2007-2012: Senior Research Scientist. National Institute of Health and Medical Research, Paris, France
2005-2007: Young Investigator Fellow. National Institute of Health and Medical Research, Paris, France
2003-2005: Research Associate. Biomedical Engineering Dept, Johns Hopkins, Baltimore, USA
2000-2003: Postdoctoral position. Biomedical Engineering Dept, Johns Hopkins, Baltimore, USA - Advisor: Pr. K. Leong
1996-1999: Ph.D. Student. University Paris 11, Paris, France - Advisor: Pr. P. Couvreur

Additional information

Recent publications

Micro-RNA-targeting nanomedicines for the treatment of intervertebral disc degeneration
H. Genedy, P. Humbert, B. Laoulaou, B. Le Moal, M. Fusellier, C. Passirani, C. Le Visage, J. Guicheux, E. Lepeltier, J. Clouet
Advanced Drug Delivery Reviews, 2024, 207: 115214
DOI: 10.1016/j.addr.2024.115214

Clickable Dynamic Bioinks Enable Post-Printing Modifications of Construct Composition and Mechanical Properties Controlled over Time and Space
P. Tournier, G. Saint-Pé, N. Lagneau, F. Loll, B. Halgand, A. Tessier, J. Guicheux , C. Le Visage, V. Delplace
Advanced Science, 2023, e2300055
DOI: 10.1002/advs.202300055

Micromolding-based encapsulation of mesenchymal stromal cells in alginate for intraarticular injection in osteoarthritis
F. Nativel*, A. Smith*, J. Boulestreau, C. Lépine, J. Baron, M. Marquis, C. Vignes, Y. Le Guennec, J. Veziers, J. Lesoeur, F. Loll, B. Halgand, D. Renard, J. Abadie, B. Legoff, F. Blanchard, O. Gauthier, C. Vinatier, A. des Rieux, J. Guicheux*, C. Le Visage*
Materials Today Bio, 2023, 100581
DOI: 10.1016/j.mtbio.2023.100581

Controlled release of biological factors for endogenous progenitor cell migration and intervertebral disc extracellular matrix remodelling
L. Frapin, J. Clouet, C. Chedeville, C. Moraru, E. Samarut, N. Henry, M. André, E. Bord, B. Halgand, J. Lesoeur, M. Fusellier, J. Guicheux*, C. Le Visage*
Biomaterials, 2020, 253: 120107
DOI: 10.1016/j.biomaterials.2020.120107

Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors
L. Frapin, J. Clouet, V. Delplace, M. Fusellier, J. Guicheux*, C. Le Visage*
Advanced Drug Delivery Reviews, 2019, 205: 81-93
DOI: 10.1016/j.addr.2019.08.007